Surgical site infection in severe trauma patients in intensive care: epidemiology and risk factors
Authors' conclusion
Our study found a high rate of SSI in severe trauma patients, although SSI was not associated with 48-month mortality.
Study context
- Population
- Severe trauma patients admitted to two ICUs of an academic institution in Marseille, 2018–2019, who underwent orthopedic or spinal surgery within 5 days after admission
- Participants
- 207 patients
- Exposure
- Surgical site infections (SSI) vs no SSI
- SSIn = 47
- Outcome
- Incidence of SSI
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
SSI incidence
SSI
23%
47
Observational data: associations, not effects.
Further findings
Mortality · 48 months
P = 0.59
SSI characteristics (fracture grade, external fixators, microbiology, empirical antibiotics)
- Cauchoix 3 grade fractures
- 22 (47%)
- SSI associated with need for external fixators
- 18 (38%)
- Polymicrobial infection
- 30 (64%)
- Due to Gram-positive cocci
- 34 (72%)
- Empirical antibiotic therapy effective
- 31 (66%)
Risk factors for SSI (multivariate analysis)
- Low hemoglobin, arterial oxygenation levels, hyperlactatemia, high serum creatinine and glycemia, and Cauchoix 3 grade on the day of surgery associated with SSI
Predictive model performance
- AUC
- 0.80 [0.73-0.88]
- NPV
- 95.9 [88.6-98.5] %
Original publication
Surgical site infection in severe trauma patients in intensive care: epidemiology and risk factors. Ann Intensive Care. Published 2 September 2024. doi:10.
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