Neuroanesthesia & neurocritical care
Control of mean arterial pressure using a closed-loop system for norepinephrine infusion in severe brain injury patients: the COMAT randomized controlled trial
Authors' conclusion
The CLV system can maintain MAP in target better than nurses caring for severe brain injury patients.
Study context
- Population
- Severe brain injury patients within the first 48 h of intensive care unit (ICU) admission
- Participants
- 18 patients
- Comparison
- Closed-loop vasopressor vs manual norepinephrine titration
- Primary endpoint
- Percentage of time patients were in target
- Follow-up
- 4-hour study period
Methodological detailsFluid administration standardized in the two groups
- Fluid administration standardized in the two groups
Primary result
As reported in the abstract
P < 0.001
Secondary outcomes
Severe undershooting (MAP < 10 mmHg of target), % time
P < 0.001
Severe overshooting (MAP > 10 mmHg of target), % time
P < 0.001
Original publication
Control of mean arterial pressure using a closed-loop system for norepinephrine infusion in severe brain injury patients: the COMAT randomized controlled trial. J Clin Monit Comput. Published 4 February 2024. doi:10.
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