Neuroanesthesia & neurocritical care
Early Vasopressor Utilization in Critically Ill Patients With Acute Traumatic Spinal Cord Injury: A Retrospective Cohort Study
Main findingResult — go to the resultOdds ratio 1.50 95% CI 1.14–1.99Authors' conclusion
Phenylephrine and norepinephrine were the most used vasopressors in SCI patients, with norepinephrine more frequently selected in patients with higher injury severity.
Study context
- Population
- Adults ≥18 y with acute traumatic spinal cord injury (SCI) at T8 or above receiving vasopressors within 48 h of hospitalization, US Premier Healthcare Database hospitals, 2016–2020
- Participants
- 3,636 adults
- Exposure
- Norepinephrine vs phenylephrine as early vasopressor
- Phenylephrinen = 2,055reference
- Norepinephrinen = 548
- Other single vasopressorn = 110
- Multiple vasopressorsn = 923
- Outcome
- Discharge to death/hospice/skilled nursing facility vs home/inpatient care facility/rehabilitation facility
Methodological detailspropensity-score standardized mortality ratio-weighted
- Propensity-score standardized mortality ratio-weighted
Main finding
As reported in the abstract
Odds ratio
1.50
95% CI 1.14–1.99
Norepinephrine vs Phenylephrine
OR 1.50 (95% CI 1.14–1.99)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| DeathNorepinephrine vs Phenylephrine | 2.04 (1.42–2.93) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Estimate (d) (95% CI) |
|---|---|
| Hospital LOSNorepinephrine vs Phenylephrine | 3.68 (1.63–5.74) |
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Urinary tract infectionsNorepinephrine vs Phenylephrine | 1.66 (1.17–2.35) | |
| Cardiac arrestNorepinephrine vs Phenylephrine | 2.70 (1.74–4.19) | |
| AKINorepinephrine vs Phenylephrine | 1.91 (1.32–2.77) | |
| TracheostomyNorepinephrine vs Phenylephrine | 1.39 (1.04–1.86) | |
| 0.20.5125Odds ratio (log scale) |
Pneumonia, thromboembolic events, cerebrovascular accidents
- No differences observed
Original publication
Early Vasopressor Utilization in Critically Ill Patients With Acute Traumatic Spinal Cord Injury: A Retrospective Cohort Study. Crit Care Med. Published 22 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →