Neuroanesthesia & neurocritical care
Effect of blood pressure threshold on adverse outcomes in patients with acute spinal cord injury: a systematic review and meta-analysis
Authors' conclusion
Lower blood pressure thresholds were consistently associated with worse functional outcomes in patients with acute SCI.
Study context
- Population
- Patients ≥ 16yrs with acute traumatic and non-traumatic spinal cord injury (SCI)14 studies in quantitative analysis
- Participants
- 2,553 patients
- Comparison
- Below vs above blood pressure threshold
- Outcome
- Adverse functional outcome by blood pressure threshold
- Follow-up
- Up to one-year post-injury
Methodological detailsrandom-effect model, PRISMA and MOOSE guidelines, Risk of bias low to moderate in most studies
- Random-effect model
- PRISMA and MOOSE guidelines
- Risk of bias low to moderate in most studies
Pooled result
As reported in the abstract
Adverse functional outcomes
Estimate (95% CI)
Below threshold vs Above threshold
uOR 3.28(2.39–4.50)
Below threshold vs Above threshold
aOR 1.04(1.03–1.05)
Further pooled results
Adverse outcomes across subgroups (subgroup)
- Lower blood pressure thresholds associated with worse outcomes across all subgroups
Original publication
Effect of blood pressure threshold on adverse outcomes in patients with acute spinal cord injury: a systematic review and meta-analysis. Crit Care. Published 16 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →