Combination of dexamethasone and dexmedetomidine as adjuvants of transversus abdominis plane block for postoperative analgesia in gastric cancer patients: A double-blinded randomized controlled trial
Authors' conclusion
The combination with dexamethasone and dexmedetomidine as adjuvants for TAP block reduced the incidence of moderate-to-severe pain and pain score both on movement and at rest at 24 h with prolonged duration to first rescue analgesia after gastric cancer surgery.
Study context
- Population
- Adults with gastric cancer receiving bilateral subcostal transversus abdominis plane (TAP) block
- Participants
- 312 adults
- Comparison
- A vs B vs C
- An = 104
- Bn = 104reference
- Cn = 104reference
- Primary endpoint
- Incidence of moderate-to-severe pain on movement
- Follow-up
- 24 h
Methodological detailsdouble-blinded
- Double-blinded
Primary result
As reported in the abstract
Relative risk (95% CI)
A vs B
0.71(0.55–0.92)
A vs C
0.62(0.49–0.79)
Secondary outcomes
Opioid consumption · first 24 h · across three groups
P = 0.01
Time to first rescue analgesia · across three groups
P = 0.04
Median
| Outcome | A | B | C | P value |
|---|---|---|---|---|
| Moving pain score · 24 hAcross three groups | 3.00 (IQR 3.00,5.00) | 4.00 (IQR 3.00,6.00) | 4.00 (IQR 3.00,5.00) | P < 0.001 |
Original publication
Combination of dexamethasone and dexmedetomidine as adjuvants of transversus abdominis plane block for postoperative analgesia in gastric cancer patients: A double-blinded randomized controlled trial. J Clin Anesth. Published 1 July 2024. doi:10.
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