The combination of interpectoral plane and superficial serratus anterior plane blocks for the prevention of persistent pain after total mastectomy: a triple‐blinded, randomised, placebo‐controlled trial
Primary resultResult — go to the resultOdds ratio 0.36 95% CI 0.13–0.98Authors' conclusion
The addition of interpectoral plane block to superficial serratus anterior plane block may reduce the incidence of rest pain at 6 months post-mastectomy.
Study context
- Population
- Adult women scheduled for total mastectomy with or without lymph node dissection
- Participants
- 100 women
- Comparison
- Intervention vs Control
- Primary endpoint
- Incidence of any pain at rest
- Follow-up
- 6 months postoperatively
Methodological detailstriple-blinded, placebo-controlled
- Triple-blinded
- Placebo-controlled
Primary result
As reported in the abstract
Odds ratio
0.36
95% CI 0.13–0.98
P = 0.044
Events by treatment group
Intervention vs Control
OR 0.36 (95% CI 0.13–0.98); P = 0.044
Secondary outcomes
Pain scores and analgesic use · 6 months postoperatively
- Pain scores very low in both groups; no patient still using analgesics
Acute pain scores and other secondary outcomes
- No differences
Original publication
The combination of interpectoral plane and superficial serratus anterior plane blocks for the prevention of persistent pain after total mastectomy: a triple‐blinded, randomised, placebo‐controlled trial. Anaesthesia. Published 26 September 2025. doi:10.
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