Comparison between ultrasound-guided multi-injection intertransverse process and thoracic paravertebral blocks for major breast cancer surgery: a randomized non-inferiority trial
Primary result · Worst resting pain score (NRS)Result — go to the resultMedian difference 0 95% CI 0–0Authors' conclusion
Compared with a multi-injection thoracic paravertebral block, the multi-injection intertransverse process block provided non-inferior analgesia within 30 min in the recovery room and recovery quality at 24 hours following major breast cancer surgery in females.
Study context
- Population
- Females undergoing mastectomy plus sentinel or axillary lymph node dissection
- Participants
- 88 females
- Comparison
- Intertransverse process block vs Thoracic paravertebral block
- Primary endpoint
- Worst resting pain score (11-point NRS) in the recovery room
- Follow-up
- Within 30 min
Methodological detailsnon-inferiority, multi-injection, ultrasound-guided
- Non-inferiority
- Multi-injection
- Ultrasound-guided
Primary result
Worst resting pain score (NRS) · within 30 min in the recovery room
Median difference
0
95% CI 0–0
non-inferiority p<0.001
By group
Intertransverse process block
0
median · IQR 0–1
Thoracic paravertebral block
0.5
median · IQR 0–2
Intertransverse process block vs Thoracic paravertebral block
median difference 0 (95% CI 0–0); non-inferiority p<0.001
As reported in the abstract
Secondary outcomes
Median
| Outcome | Intertransverse process block | Thoracic paravertebral block | Median difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Recovery quality (QoR-15 aggregate score) · 24 hours postoperativelyLower 95% CI limit larger than non-inferiority margin of −8 · gatekeeping procedure | 137.5 (IQR 126.5–142.8) | 137.5 (IQR 127.8–145.0) | −1 (−6 to 3) | non-inferiority p=0.006 | |
| −10−505Difference (linear scale) |
- Recovery quality (QoR-15 aggregate score): non-inferiority margin −8; non-inferior
Original publication
Comparison between ultrasound-guided multi-injection intertransverse process and thoracic paravertebral blocks for major breast cancer surgery: a randomized non-inferiority trial. Reg Anesth Pain Med. Published 15 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →