Combined Fascia Iliaca Compartment-Sciatic Nerve Blocks Reduce Early Cardiovascular Events in Chronic Limb-Threatening Ischemia: A Propensity Score–Matched Retrospective Study
Main finding · In-hospital MACEResult — go to the resultOdds ratio 0.49 95% CI 0.18–1.32Authors' conclusion
FICB-SNB improves analgesia but does not significantly reduce short- or long-term MACE.
Study context
- Population
- Patients with chronic limb-threatening ischemia (CLTI) undergoing lower-extremity revascularization
- Participants
- 432 patients · 216 matched pairs
- Exposure
- Combined FICB-SNB vs monitored anesthesia care (MAC)
- FICB-SNBn = 216
- MACn = 216reference
- Outcome
- In-hospital MACE and 1-year MACE
Methodological details1:1 propensity score matching, single-centre
- 1:1 propensity score matching
- Single-centre
Main finding
In-hospital MACE
Odds ratio
0.49
95% CI 0.18–1.32
P = 0.15
FICB-SNB vs MAC
OR 0.49 (95% CI 0.18–1.32); P = 0.15
As reported in the abstract
- 1-year major adverse cardiovascular events (MACE) not significantly reduced
- P > 0.05
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Rest painRest pain reduced by 67% | 0.33 (0.23–0.48) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Safety
MINS, complications, amputation
- No differences observed
- P > 0.05 for all
Original publication
Combined Fascia Iliaca Compartment-Sciatic Nerve Blocks Reduce Early Cardiovascular Events in Chronic Limb-Threatening Ischemia: A Propensity Score–Matched Retrospective Study. J Cardiothorac Vasc Anesth. Published 14 August 2025. doi:10.
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