Community-acquired Klebsiella pneumoniae pneumonia in ICU: a multicenter retrospective study
Authors' conclusion
We described a strong association between KP-CAP infection and higher and earlier mortality when compared to SP-CAP. Moreover, alcoholism was the sole predisposing factor associated with KP-CAP infection.
Study context
- Population
- ICU patients with community-acquired pneumonia, 7 ICUs in France, 2015–20197 ICUs
- Participants
- 27 vs 81
- Exposure
- Klebsiella pneumoniae CAP vs Streptococcus pneumoniae CAP
- KP-CAPn = 27
- Streptococcus pneumoniae - CAP (SP-CAP)n = 81reference
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, matched (3 SP-CAP per KP-CAP, same centre and 6-month window)
- Multicentre
- Matched (3 SP-CAP per KP-CAP, same centre and 6-month window)
Main finding
As reported in the abstract
- KP-CAP vs SP-CAP: P < 0.001
Observational data: associations, not effects.
Further findings
Multiple organ failures
P < 0.001
Disseminated intravascular coagulation
P = 0.046
Kidney failure (KDIGO-3)
P < 0.001
Septic shock (lactate on ICU admission)
P = 0.030
- Time from admission to death (KP-CAP)
- 26.9 · median · IQR 5.75-44 h · h
Predisposing factors of KP-CAP
- Alcoholism the only identified predisposing factor of KP-CAP
Factors associated with mortality (multivariate analysis)
- Severity on ICU admission (2-fold higher for KP-CAP) the only factor associated with mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Community-acquired Klebsiella pneumoniae pneumonia in ICU: a multicenter retrospective study. Ann Intensive Care. Published 30 April 2024. doi:10.
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