Comparative dose–response study of intrathecal hyperbaric ropivacaine for cesarean delivery in preterm singleton versus twin pregnancies
Authors' conclusion
During preterm gestation, intrathecal hyperbaric ropivacaine dose requirements for scheduled cesarean delivery were not different between patients with twins and singletons.
Study context
- Population
- Patients with preterm singleton or twin pregnancies scheduled for cesarean delivery under CSE
- Participants
- 75 vs 75
- Comparison
- Twins vs Singletons
- Twinsn = 75
- Singletonsn = 75reference
- Primary endpoint
- ED50 and ED90 of intrathecal hyperbaric ropivacaine (probit regression)
Methodological detailstwo-arm parallel, double-blind, dose-response
- Two-arm parallel
- Double-blind
- Dose-response
Primary result
ED50 and ED90
Relative potency (ED50 ratio)
0.933
95% CI 0.72–1.15
By group
As reported in the abstract
Original publication
Comparative dose–response study of intrathecal hyperbaric ropivacaine for cesarean delivery in preterm singleton versus twin pregnancies. Reg Anesth Pain Med. Published 30 October 2023. doi:10.
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