Cardiac arrest & resuscitation
Comparative Effectiveness of Lidocaine and Amiodarone for Refractory Ventricular Fibrillation (VF)/Pulseless Ventricular Tachycardia (pVT) in Adult In-Hospital Cardiac Arrest: Insights from a Nationwide Multicenter Chinese Registry
Authors' conclusion
We observed no significant differences in outcomes between the two agents
Study context
- Population
- Adults with in-hospital cardiac arrest (IHCA) and refractory VF/pVT receiving lidocaine or amiodarone, BASIC-IHCA registry, China, July 2019–December 2020of 32,545 adult IHCA cases
- Participants
- 612 adults
- Exposure
- Lidocaine vs amiodarone for refractory VF/pVT
- Lidocainen = 259
- Amiodaronen = 353reference
- Outcome
- Survival to hospital discharge or 30 days
- Follow-up
- Hospital discharge or 30 days
Methodological detailsnationwide, multicentre, 40 hospitals, adjudicated cases, multilevel mixed-effects logistic regression, prespecified subgroup analyses
- Nationwide
- Multicentre
- 40 hospitals
- Adjudicated cases
- Multilevel mixed-effects logistic regression
- Prespecified subgroup analyses
Main finding
As reported in the abstract
- Lidocaine vs Amiodarone: P = 0.31
- Consistent exploratory subgroup findings
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| Sustained ROSCUnadjusted | P = 0.38 |
| Favourable neurological outcome (CPC 1/2) · discharge or 30 daysUnadjusted | P = 0.22 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparative Effectiveness of Lidocaine and Amiodarone for Refractory VF/pVT in Adult In-Hospital Cardiac Arrest: Insights from a Nationwide Multicenter Chinese Registry. Chest. Published 21 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →