Cardiac arrest & resuscitation
Comparative Effectiveness of Amiodarone and Lidocaine for the Treatment of In-Hospital Cardiac Arrest
Authors' conclusion
Compared with amiodarone, lidocaine therapy among adult patients with in-hospital cardiac arrest from VT/VF was associated with statistically significantly higher rates of ROSC, 24 h survival, survival to hospital discharge, and favorable neurologic outcome.
Study context
- Population
- Adults with VT/VF IHCA refractory to CPR and defibrillation, Get With the Guidelines-Resuscitation (GWTG-R) hospitals, 2000–2014
- Participants
- 14,630 adults
- Exposure
- Lidocaine vs amiodarone
- Lidocainen = 4,572
- Amiodaronen = 10,058reference
- Outcome
- ROSC
Methodological detailsmulticentre registry, multivariable logistic regression, propensity score methods
- Multicentre registry
- Multivariable logistic regression
- Propensity score methods
Main finding
As reported in the abstract
AOR for return of spontaneous circulation (ROSC)
1.15
P = 0.01
adjusted for all covariates
Average marginal effect for ROSC
2.3
95% CI 0.5–4.2
ROSC
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | P value |
|---|---|---|
| 24 h survivalLidocaine vs Amiodarone | aOR for 24 h survival 1.16 | P = 004 |
| 24 h survivalLidocaine vs Amiodarone | average marginal effect for 24 h survival 3.0 (95% CI 0.9–5.1) | |
| Survival to hospital dischargeLidocaine vs Amiodarone | aOR for survival to discharge 1.19 | P < 0.001 |
| Survival to hospital dischargeLidocaine vs Amiodarone | average marginal effect for survival to discharge 3.3 (95% CI 1.5–5.2) | |
| Favorable neurologic outcome at hospital dischargeLidocaine vs Amiodarone | aOR for favorable neurologic outcome 1.18 | P < 0.001 |
| Favorable neurologic outcome at hospital dischargeLidocaine vs Amiodarone | average marginal effect for favorable neurologic outcome 3.1 (95% CI 1.3–4.9) |
Original publication
Comparative Effectiveness of Amiodarone and Lidocaine for the Treatment of In-Hospital Cardiac Arrest. Chest. Published 2 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →