Comparative efficacy of landiolol and bisoprolol transdermal patch in patients with sepsis-related tachycardia: a retrospective cohort study
Authors' conclusion
Landiolol and the bisoprolol transdermal patch achieved comparable 24-h HR control in the overall cohort of sepsis patients with tachycardia.
Study context
- Population
- Adults with sepsis-related tachycardia (HR ≥ 100 bpm) in intensive care units (ICUs) of a Japanese ICU database, January 2014 to March 2026after propensity score matching (PSM)
- Participants
- 950 adults
- Exposure
- IV landiolol vs bisoprolol transdermal patch
- Landiololn = 475
- Bisoprololn = 475reference
- Outcome
- Proportion achieving HR control (60-94 bpm)
- Follow-up
- 24 h
Methodological detailsmulticentre, propensity-score matched (1:1)
- Multicentre
- Propensity-score matched (1:1)
Main finding
As reported in the abstract
P = 0.561
Observational data: associations, not effects.
Secondary outcomes
HR control, septic shock (subgroup) · 24 h
P = 0.046
In-hospital mortality
P = 0.088
Increased norepinephrine-equivalent dose required · 24 h · comparable between groups
P = 0.170
HR trend over 24 h
- Landiolol achieved a more rapid HR reduction, whereas bisoprolol induced a moderate decrease in HR
Safety
Bradycardia · comparable between groups
P = 0.174
Original publication
Comparative efficacy of landiolol and bisoprolol transdermal patch in patients with sepsis-related tachycardia: a retrospective cohort study. J Intensive Care. Published 5 August 2026. doi:10.
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