Haemodynamics, fluids & transfusion
Comparative epidemiology of intraoperative hypotension and hypoxemia across three large retrospective cohorts
Authors' conclusion
Hypotension and hypoxemia rarely co-occurred and had distinct preoperative associations, but each was independently associated with outcomes.
Study context
- Population
- Noncardiac surgical cases in three retrospective cohorts (INSPIRE, MOVER, MSHS)cases, 3 cohorts
- Participants
- 165,646 cases
- Exposure
- Hypotension vs Hypoxemia
- Outcome
- Prevalence
Methodological detailsthree cohorts (INSPIRE, MOVER, MSHS), noncardiac surgery, logistic regression
- Three cohorts (INSPIRE, MOVER, MSHS)
- Noncardiac surgery
- Logistic regression
Main finding
As reported in the abstract
Hypotension
12.7-28.8%
Hypoxemia
2.3-4.9%
- Co-occurrence of hypotension and hypoxemia
- <1% of cases
Observational data: associations, not effects.
Further findings
Association with acute kidney injury (AKI), non-routine ICU admission and in-hospital mortality (binary events, mutually adjusted)
- Binary hypoxemia associated with all three outcomes
- Binary hypotension associated with ICU admission and mortality but not AKI
- AKI analyses all cohorts; ICU and mortality analyses INSPIRE and MSHS
Association of time-weighted average (TWA) burden (TWA-MAP, TWA-SpO2) with outcomes
- TWA-MAP and TWA-SpO2 each showed graded associations with all three outcomes
- TWA-SpO2 estimates for ICU admission and mortality from MSHS alone
Timing among event-positive cases
- Post-induction hypotension
- 64.8-88.1%
- Mid-case hypoxemia
- 14.9-51.2%
- Not associated with outcomes beyond TWA burden
Original publication
Comparative epidemiology of intraoperative hypotension and hypoxemia across three large retrospective cohorts. Anaesth Crit Care Pain Med. Published 22 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →