Comparative evaluation of nebulized versus intravenous dexmedetomidine on intubating conditions during awake fiberoptic nasotracheal intubation
Authors' conclusion
Nebulisation with dexmedetomidine results in desirable degree of sedation and better tolerance of the procedure with adequate attenuation of the haemodynamic responses to intubation.
Study context
- Population
- ASA I/II adults scheduled for elective ENT surgery undergoing awake fiberoptic nasotracheal intubation
- Participants
- 46 adults
- Comparison
- ND vs ID
- NDn = 23
- IDn = 23reference
- Primary endpoint
- Cough score
Methodological detailsdouble-blind, All patients received midazolam 1 mg i.v. as premedication
- Double-blind
- All patients received midazolam 1 mg i.v. as premedication
Primary result
As reported in the abstract
Cough score, nebulized vs comparator (values as printed)
2.43 ± 0.992 vs 3.52 ± 1.082
Secondary outcomes
- RSS — RSS, nebulized vs comparator (values as printed) · significantly lower in nebulized group
- 3.30 ± 0.926 vs 4.22 ± 1.126 · P = 0.004
- Number of SAYGO boluses required — SAYGO boluses, nebulized vs comparator (values as printed) · significantly lower in nebulized group
- 2.74 ± 0.864 vs 3.57 ± 1.161 · P = 0.009
- Post-intubation score — Post-intubation score, nebulized vs comparator (values as printed) · significantly lower in nebulized group
- 1.48 ± 0.593 vs 2.17 ± 0.778 · P = 0.001
Original publication
Comparative evaluation of nebulized versus intravenous dexmedetomidine on intubating conditions during awake fiberoptic nasotracheal intubation. J Clin Anesth. Published 11 April 2024. doi:10.
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