Comparative Methods to Predict Redosing of Bupivacaine and Ropivacaine in Truncal Catheters
Authors' conclusion
Clinically reported redosing of bupivacaine and ropivacaine in the published literature reflect the slowest pharmacokinetic elimination based on human studies.
Study context
- Population
- Published clinical intermittent bolus redosing into the transversus abdominis plane and paravertebral space, and published human pharmacokinetic studies
- Comparison
- Clinically reported redosing vs pharmacokinetic elimination of bupivacaine and ropivacaine
- Outcome
- Clinical redosing elimination constant compared with pharmacokinetic elimination constants
Methodological detailsliterature-based, exponential curve fitting (least squares regression, 1/Y 2 weighting)
- Literature-based
- Exponential curve fitting (least squares regression, 1/Y 2 weighting)
Main finding
As reported in the abstract
Clinical redosing elimination constant (k) and percentile of minimal pharmacokinetic elimination constants
| Group | Value | Percentile of minimal pharmacokinetic elimination constants |
|---|---|---|
| Bupivacaine | 0.077 h −1 | 53.5th |
| Ropivacaine | 0.083 h −1 | 52nd |
Value
Bupivacaine0.077 h −1
Ropivacaine0.083 h −1
Percentile of minimal pharmacokinetic elimination constants
Bupivacaine53.5th
Ropivacaine52nd
Further findings
Maximal pharmacokinetic half-life
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparative Methods to Predict Redosing of Bupivacaine and Ropivacaine in Truncal Catheters. Anesthesiology. Published 5 February 2025. doi:10.
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