Comparative study of the efficacy and safety of remimazolam and midazolam for general anesthesia in elderly patients: a randomized controlled trial
Authors' conclusion
General anesthesia with remimazolam has been shown to be effective and safe for surgery in elderly patients. The time to extubation was significantly shorter, length of PACU stay was shorter, and percentage of flumazenil used was lower in the remimazolam group than in the midazolam group.
Study context
- Population
- Patients aged 65 years or older scheduled for surgery under GA, university hospital, February 2022–March 202396 analysed
- Participants
- 100 patients
- Comparison
- Remimazolam vs midazolam for GA
- Remimazolamn = 46
- Midazolamn = 50reference
- Primary endpoint
- Time to loss of consciousness
Methodological detailssingle-centre, Randomised into 2 groups of 50 each
- Single-centre
- Randomised into 2 groups of 50 each
Primary result
As reported in the abstract
P = 0.000
Secondary outcomes
Time to extubation · significant difference
P = 0.003
PACU LOS · difference significant
P = 0.001
Flumazenil use · difference significant
P = 0.003
Original publication
Comparative study of the efficacy and safety of remimazolam and midazolam for general anesthesia in elderly patients: a randomized controlled trial. Perioper Med (Lond). Published 8 May 2025. doi:10.
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