Respiratory failure & ventilation
Comparing Cardiac Output Differences in Patients With Fontan Physiology Between High and Low Tidal Volume Strategies: A Randomized, Crossover Trial
Authors' conclusion
While there was no significant difference in cardiac index between the two ventilation strategies in the direct comparison, we did obtain data showing lower tidal volume may be favorable for maintaining cardiac index for some Fontan patients requiring positive pressure ventilation.
Study context
- Population
- Fontan patients < 18 years old presenting for cardiac catheterization requiring intubation and positive pressure ventilation30 completed protocol
- Comparison
- High vs low tidal volume strategy
- Primary endpoint
- Systemic cardiac index (clinically significant difference 0.7 L/min/m²)
Methodological detailscrossover
- Crossover
Primary result
As reported in the abstract
Cardiac index
P = 0.062
Further findings
Patients meeting clinically significant difference threshold, among those with higher cardiac index in each strategy
Cohen's h 0.186
- Patients meeting clinically significant difference threshold, among those with higher cardiac index in each strategy: 3/9 vs 8/19
Original publication
Comparing Cardiac Output Differences in Patients With Fontan Physiology Between High and Low Tidal Volume Strategies: A Randomized, Crossover Trial. Paediatr Anaesth. Published 24 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →