Comparing the haemodynamic effects of high- and low-dose opioid anaesthesia: a secondary analysis of a randomised controlled trial
Authors' conclusion
Induction of anaesthesia with different predicted equipotent combinations of propofol and remifentanil did result in statistically different but clinically irrelevant differences in haemodynamic endpoints during induction of anaesthesia.
Study context
- Population
- Patients undergoing induction of anaesthesia with propofol and remifentanil
- Participants
- 76 patients
- Comparison
- Four equipotent (predicted probability of tolerance to laryngoscopy (PTOL)) propofol–remifentanil combinations for induction, from high propofol/low remifentanil (A) to the reverse (D)
- Primary endpoint
- MAP and SAP at Tbaseline, Tpost-bolus, T3min and Tnadir
Methodological detailsDoses titrated to predicted equipotent PTOL per the Bouillon interaction model
- Doses titrated to predicted equipotent PTOL per the Bouillon interaction model
Primary result
As reported in the abstract
MAP and SAP · Tpost-bolus
- A vs D: P = 0.011
- A vs D: P = 0.002
Further findings
| Outcome | P value |
|---|---|
| Heart rate · T3min and TnadirA and B vs C and D | P = < 0.001 and p = 0.002 |
BIS · T3min and Tnadir
- Significant difference in BIS value over all groups
- both p < 0.001
Incidence of hypotension and all other outcomes
- Did not differ significantly between groups
Original publication
Comparing the haemodynamic effects of high- and low-dose opioid anaesthesia: a secondary analysis of a randomised controlled trial. J Clin Monit Comput. Published 20 July 2024. doi:10.
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