The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial)
Authors' conclusion
Among critically ill ECMO patients receiving CRRT, there is no significant difference in filter lifespan and serious adverse events between integrating the CRRT circuit into the ECMO circuit and using a separate circuit.
Study context
- Population
- Extracorporeal membrane oxygenation (ECMO) patients requiring CRRT support
- Participants
- 80 patients
- Comparison
- Integration of CRRT circuit into ECMO circuit vs separate CRRT circuit
- Integrationn = 40
- Separationn = 40reference
- Primary endpoint
- CRRT circuit lifespan
Methodological detailsmulticentre, Conducted May 2021 to March 2025
- Multicentre
- Conducted May 2021 to March 2025
Primary result
As reported in the abstract
- Integration vs Separation: P = 0.52
Further findings
| Outcome | P value |
|---|---|
| 28-day mortality · comparable | P = 0.81 |
Transmembrane pressure and CRRT machine alarm frequencies
- Similar between groups
Safety
Serious adverse events, including air embolism
- No significant differences between groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial). Intensive Care Med. Published 5 February 2026. doi:10.
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