Comparison of the approaches to combine Renal Replacement Therapy with Extracorporeal Membrane Oxygenation – a Scoping Review
Authors' conclusion
Evidence on ECMO-RRT configurations is limited and heterogeneous.
Study context
- Population
- Studies comparing at least 2 ECMO-RRT configurations (patients on extracorporeal membrane oxygenation (ECMO) for cardiac or respiratory failure requiring renal replacement therapy (RRT))studies included
- Participants
- 20 studies
- Comparison
- Integrated vs parallel ECMO-RRT configurations
- Outcome
- Efficiency and clinical outcomes
Methodological detailsSearched PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov without restrictions; final search February 9, 2026
- Searched PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov without restrictions; final search February 9, 2026
Main finding
As reported in the abstract
- No consistent differences in efficiency or clinical outcomes between configurations compared
- Integrated methods associated with longer or comparable hemofilter lifespan
- 12 clinical (1 RCT), 3 in vitro, 1 in silico, 4 surveys
- More than 8 ECMO-RRT connection schemes described since 2013
Further findings
Medical practice (surveys)
- Heterogeneous medical practices
Safety
Safety concerns (surveys)
- Safety concerns reported (unstoppable pressure alarms and air embolism)
- 2
Original publication
Comparison of the approaches to combine Renal Replacement Therapy with Extracorporeal Membrane Oxygenation – a Scoping Review. Ann Intensive Care. Published 21 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →