The use of oXiris hemofilter in the initial continuous renal replacement therapy among patients with septic shock: A propensity score matched analysis
Authors' conclusion
In this cohort of septic shock patients undergoing CRRT, unadjusted analyses demonstrated potential improvements in hemodynamic stability and organ function following oXiris therapy. Nevertheless, these preliminary signals were not confirmed by competing risk analysis of the primary outcome.
Study context
- Population
- Adults with septic shock admitted to the intensive care unit (ICU) of a tertiary referral hospital, 2019–2023, with at least one continuous renal replacement therapy (CRRT) session69 per group matched
- Participants
- 465 adults
- Exposure
- oXiris hemofilter vs M100 hemofilter in the initial CRRT
- Outcome
- Vasopressor-free days
- Follow-up
- 28 days
Methodological detailssingle-center, 1:1 propensity score matching
- Single-center
- 1:1 propensity score matching
Main finding
As reported in the abstract
28-day vasopressor-free days
P = 0.04
Observational data: associations, not effects.
Further findings
CRRT duration
P = 0.03
| Outcome | oXiris | M100 | P value |
|---|---|---|---|
| Change in SOFA score | −2 | 1 | P = 0.004 |
Changes in lactate, PCT, IL-6; fluid balance; ICU and hospital length of stay (LOS); short-term mortality
- No significant between-group differences
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The use of oXiris hemofilter in the initial continuous renal replacement therapy among patients with septic shock: A propensity score matched analysis. J Crit Care. Published 24 June 2026. doi:10.
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