Continuous renal replacement therapy with the adsorptive oXiris filter may be associated with the lower 28-day mortality in sepsis: a systematic review and meta-analysis
Pooled result · 28-day mortalityResult — go to the resultOdds ratio 0.53 95% CI 0.36–0.77Authors' conclusion
The treatment with the oXiris filter during CRRT in sepsis patients may be associated with lower 28-, 7-, and 14-day mortalities, lactate levels, SOFA score, NE dose, and shorter length of ICU stay.
Study context
- Population
- Patients with sepsis receiving continuous renal replacement therapy (CRRT)
- Participants
- 695 patients · 14 studies
- Comparison
- CRRT with oXiris filter vs other filters
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsGrading of Recommendations, Assessment, Development, and Evaluation (GRADE) certainty assessment, 10 observational studies of intermediate to high quality (average Newcastle-Ottawa score 7.8); all 4 randomized controlled trials (RCTs) unclear risk of bias
- GRADE certainty assessment
- 10 observational studies of intermediate to high quality (average Newcastle-Ottawa score 7.8); all 4 RCTs unclear risk of bias
Pooled result
As reported in the abstract
Odds ratio
0.53
95% CI 0.36–0.77
P = 0.001
oXiris vs Other filters
OR 0.53 (95% CI 0.36–0.77); P = 0.001
Further pooled results
| Outcome | Weighted mean difference (95% CI) | P value |
|---|---|---|
| ICU LOS | - 1.91 (- 2.56 to - 1.26) | P < 0.001 |
Sequential Organ Failure Assessment (SOFA) score, norepinephrine (NE) dose, IL-6 and lactate levels, 7- and 14-day mortality
- Lower in the oXiris group
90-day mortality, intensive care unit (ICU) and hospital mortality, hospital LOS
- Comparable
Original publication
Continuous renal replacement therapy with the adsorptive oXiris filter may be associated with the lower 28-day mortality in sepsis: a systematic review and meta-analysis. Crit Care. Published 9 July 2023. doi:10.
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