Comparison of the Diagnostic Accuracies of Monocyte Distribution Width, Procalcitonin, and C-Reactive Protein for Sepsis: A Systematic Review and Meta-Analysis
Authors' conclusion
The results of the meta-analysis indicate that MDW is a reliable diagnostic biomarker for sepsis as procalcitonin and CRP.
Study context
- Population
- Adults with sepsis (Sepsis-2 or Sepsis-3 criteria)18 studies
- Comparison
- Monocyte distribution width (MDW) vs procalcitonin and C-reactive protein (CRP) for sepsis diagnosis
- Outcome
- Diagnostic accuracy of MDW for sepsis
Methodological detailsTwo independent reviewers; PubMed, Embase, Cochrane Library searched to October 1, 2022
- Two independent reviewers; PubMed, Embase, Cochrane Library searched to October 1, 2022
Pooled result
As reported in the abstract
Pooled diagnostic accuracy of MDW
| Group | Sensitivity | Specificity | Diagnostic OR | AUC (SROC) |
|---|---|---|---|---|
| MDW | 84% (95% CI 79-88%) | 68% (95% CI 60-75%) | 11.11 (95% CI 7.36-16.77) | 0.85 (95% CI 0.81-0.89) |
MDW
Sensitivity84% (95% CI 79-88%)
Specificity68% (95% CI 60-75%)
Diagnostic OR11.11 (95% CI 7.36-16.77)
AUC (SROC)0.85 (95% CI 0.81-0.89)
Further pooled results
| Outcome | MDW | Procalcitonin | CRP |
|---|---|---|---|
| AUC (SROC), MDW vs procalcitonin (8 studies) | |||
| AUC (SROC) | 0.88, CI = 0.84-0.93 | 0.82, CI = 0.76-0.88 | — not stated in the abstract |
| AUC (SROC), MDW vs CRP (5 studies) | |||
| AUC (SROC) | 0.88, CI = 0.83-0.93 | — not stated in the abstract | 0.86, CI = 0.78-0.95 |
— not stated in the abstract
AUC (SROC), MDW vs procalcitonin (8 studies)
- Area under the SROC similar
AUC (SROC), MDW vs CRP (5 studies)
- Area under the SROC similar
Original publication
Comparison of the Diagnostic Accuracies of Monocyte Distribution Width, Procalcitonin, and C-Reactive Protein for Sepsis: A Systematic Review and Meta-Analysis. Crit Care Med. Published 6 March 2023. doi:10.
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