Comparison of the hemodynamic effects of opioid-based versus lidocaine-based induction of anesthesia with propofol in older adults: a randomized controlled trial
Authors' conclusion
Lidocaine-based regimen for induction of anesthesia reduced the risk of postinduction hypotension in older patients compared to the fentanyl-based regimen.
Study context
- Population
- Patients aged above 60 years undergoing elective non-cardiac surgery47 and 46 analysed
- Participants
- 50 vs 50
- Comparison
- Lidocaine 1 mg/kg vs fentanyl 1 mcg/kg with propofol induction of GA
- Lidocainen = 50
- Fentanyln = 50reference
- Primary endpoint
- Norepinephrine requirements
Primary result
As reported in the abstract
Norepinephrine dose
Fentanyl
4
median · IQR 0,5 · mcg
P < 0.001
Further findings
| Outcome | Lidocaine | Fentanyl | P value |
|---|---|---|---|
| Postinduction hypotension | 0 events | 61% | P < 0.001 |
MAP
- Average MAP lower with fentanyl than lidocaine at all time points after induction
Heart rate
- Comparable between groups nearly at all time points
Intubation condition
- Overall intubation condition comparable between groups
Safety
- None of the included patients developed postoperative delirium
- 0
Original publication
Comparison of the hemodynamic effects of opioid-based versus lidocaine-based induction of anesthesia with propofol in older adults: a randomized controlled trial. Anaesth Crit Care Pain Med. Published 6 April 2023. doi:10.
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