Pediatric anesthesia & critical care
Comparison of Inhalational and Intravenous Anesthesia Induction on Electroencephalogram and Cerebral Perfusion in Children With Congenital Heart Disease: A Secondary Analysis of a Randomized Controlled Trial
Authors' conclusion
The administration of sevoflurane for anesthesia induction results in more burst suppression, while also demonstrating superior cerebral perfusion when compared with the use of intravenous medications for anesthesia induction.
Study context
- Population
- Children with congenital heart disease undergoing cardiac surgery, 2 tertiary hospitals
- Participants
- 116 children
- Comparison
- Inhalational vs intravenous anaesthesia induction
- Inhalationaln = 58
- Intravenousn = 58reference
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
EEG and cerebral perfusion 10 min after tracheal intubation · Ten minutes after tracheal intubation
- Inhalational vs Intravenous: significant increases in 95% spectral edge frequency, ratio of burst suppression event, middle cerebral artery blood flow velocity and cerebral oxygen saturation
- p < 0.05 for all
Further findings
Hemodynamic parameters · Ten minutes after tracheal intubation
- Inhalational vs Intravenous: decreases in systolic pressure, diastolic pressure, cardiac index and maximal slope of systolic upstroke
- P < 0.05 for all
Original publication
Comparison of Inhalational and Intravenous Anesthesia Induction on Electroencephalogram and Cerebral Perfusion in Children With Congenital Heart Disease: A Secondary Analysis of a Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 22 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →