Pediatric anesthesia & critical care
Comparison of intravenous and inhalation anesthesia on postoperative behavior changes in children undergoing ambulatory endoscopic procedures: A randomized clinical trial
Authors' conclusion
The incidence of postoperative behavior changes in children undergoing ambulatory endoscopic procedures was similar when comparing intravenous with inhalation anesthesia.
Study context
- Population
- Children aged 1–12 years undergoing ambulatory endoscopic proceduresenrolled
- Participants
- 175 children
- Comparison
- Propofol vs sevoflurane maintenance after sevoflurane mask induction
- Primary endpoint
- Postoperative behavior changes (Posthospitalization Behavior Questionnaire for Ambulatory Surgery)
- Follow-up
- Days 1, 7, and 14
Methodological detailsdouble-blinded
- Double-blinded
Primary result
As reported in the abstract
Postoperative negative behaviors
Children with ≥1 negative behavior on Day 1 (overall)
57
Children with ≥1 negative behavior on Day 7 (overall)
49
Children with ≥1 negative behavior on Day 14 (overall)
44
Further findings
Emergence delirium and negative postoperative behavior (post hoc) · Day 7
- Correlation between emergence delirium and negative behavior on Day 7 (moderate)
- r = .34; p = <.001
- Increase in mean summed score of new negative behaviors with emergence delirium (points)
- 3.31 (95% CI 1.90; 4.36 p < .001)
- Post hoc analyses
Original publication
Comparison of intravenous and inhalation anesthesia on postoperative behavior changes in children undergoing ambulatory endoscopic procedures: A randomized clinical trial. Paediatr Anaesth. Published 18 November 2022. doi:10.
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