Pediatric anesthesia & critical care
Respiratory Adverse Events After LMA® Mask Removal in Children: A Randomized Trial Comparing Propofol to Sevoflurane
Primary result · Respiratory adverse eventsResult — go to the resultRelative risk 0.29 95% CI 0.14–0.64Authors' conclusion
Propofol induction and maintenance exerted a protective effect on healthy children with minimal risk factors for developing perioperative respiratory complications, as compared to sevoflurane.
Study context
- Population
- Children aged 6 months to 7 years with LMA, mechanically ventilated
- Comparison
- Total intravenous anesthesia (TIVA) with propofol vs sevoflurane
- Primary endpoint
- At least 1 respiratory adverse event, individual respiratory adverse events and airway hyperreactivity score following emergence from anesthesia
Methodological detailsprospective, double-blind
- Prospective
- Double-blind
Primary result
Respiratory adverse events
Relative risk
0.29
95% CI 0.14–0.64
P = 0.001
By group
TIVA
10.8.%
Sevoflurane
36.2%
TIVA vs Sevoflurane
RR 0.29 (95% CI 0.14–0.64); P = 0.001
As reported in the abstract
Secondary outcomes
| Outcome | P value |
|---|---|
| Emergence agitationMore frequent with sevoflurane | P < 0.001 |
Ease of LMA insertion, quality of anesthesia during maintenance, hemodynamic stability, time to LMA removal
- No statistically significant differences between the 2 groups
Original publication
Respiratory Adverse Events After LMA® Mask Removal in Children: A Randomized Trial Comparing Propofol to Sevoflurane. Anesth Analg. Published 25 February 2022. doi:10.
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