Pediatric anesthesia & critical care
Effect of Intravenous, Inhalational, or Combined Anesthesia Maintenance on Postoperative Respiratory Adverse Events in Children Undergoing Adenotonsillectomy (AmPRAEC): A Multicenter Randomized Clinical Trial
Authors' conclusion
Anesthesia maintenance with propofol infusion in addition to inhalation anesthesia or alone resulted in a progressive reduction in the incidence of PRAEs.
Study context
- Population
- Children aged 0 to 12 yr undergoing adenotonsillectomy with tracheal tube and awake extubation, 12 hospitals in China729 analysed (modified ITT)
- Participants
- 760 children
- Comparison
- IV vs combined IV-inhalation vs inhalation anaesthesia maintenance
- IVn = 239
- IVIHn = 246
- IHn = 244reference
- Primary endpoint
- PRAE incidence in the PACU
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Postoperative respiratory adverse events (PRAEs) in PACU
Adjusted odds ratio (95% CI)
IVIH vs IHNNT 7
0.44(0.29–0.65)
IV vs IVIHNNT 6
0.57(0.36–0.90)
IV vs IHNNT 3
0.25(0.16–0.39)
Original publication
Effect of Intravenous, Inhalational, or Combined Anesthesia Maintenance on Postoperative Respiratory Adverse Events in Children Undergoing Adenotonsillectomy (AmPRAEC): A Multicenter Randomized Clinical Trial. Anesthesiology. Published 6 August 2025. doi:10.
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