Pediatric anesthesia & critical care
Comparison of Different Treatments of Persistent Pulmonary Hypertension of the Newborn: A Systematic Review and Network Meta-Analysis*
Authors' conclusion
MNO + OSID is the most effective PPHN treatment.
Study context
- Population
- Neonates with persistent pulmonary hypertension of the newborn (PPHN)
- Participants
- 902 neonates · 23 RCTs
- Comparison
- 16 treatment strategies vs each other and conventional therapy
- Outcome
- Efficacy and mortality of PPHN therapies
Methodological detailsrandom-effects, SUCRA ranking, Searched PubMed, Embase and Cochrane Library up to January 27, 2023
- Random-effects
- SUCRA ranking
- Searched PubMed, Embase and Cochrane Library up to January 27, 2023
Pooled result
As reported in the abstract
Efficacy
Each group vs CONOdds ratio (95% CI)
MNO + OSIDSUCRA = 0.818, ranking first; moderate quality
27.53(2.36–321.75)
OSID + milrinoneSUCRA = 0.811, ranking second; low quality
25.13(1.67–377.78)
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Mortality reductionCON vs OSID + milrinone · SUCRA = 0.786, ranking last; low quality | 25.13 (1.67–377.78) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Comparison of Different Treatments of Persistent Pulmonary Hypertension of the Newborn: A Systematic Review and Network Meta-Analysis*. Crit Care Med. Published 16 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →