Pediatric anesthesia & critical care
Safety of Intrathecal Clonidine as an Adjuvant to Spinal Anesthesia in Infants and Children
Authors' conclusion
Based on this retrospective, observational study, clonidine appears to be a safe adjuvant to spinal anesthesia for ambulatory surgical procedures in infants and children.
Study context
- Population
- Neonates, infants and children (newborn to 36 months, median age 7 months) undergoing spinal anaesthesia for ambulatory surgery
- Participants
- 1,420 neonates
- Outcome
- Safety of clonidine as an adjuvant to spinal anaesthesia
Methodological detailssingle-group, 5-6-year experience
- Single-group
- 5-6-year experience
Main finding
As reported in the abstract
Intraoperative and postoperative course
- Tolerated spinal anaesthesia without conversion to GA
- 95%
- No additional intraoperative sedation
- over 73%
- Post Anesthesia Care Unit (PACU) Phase I bypassed
- 75%
- Postoperative admission rate
- 7%
- Planned admissions among admissions
- 85%
Observational data: associations, not effects.
Safety
Intraoperative hypotension (sBP ≤ 60 mmHg)
- Hypotension, most common intraoperative event
- 17%
- Anticholinergic agent required for bradycardia (patients)
- 1
Serious intraoperative adverse events
- No serious intraoperative adverse events noted
Return to hospital, primarily for surgical concerns · first seven postoperative days
- Patients returned to hospital
- 56 (4%)
Original publication
Safety of Intrathecal Clonidine as an Adjuvant to Spinal Anesthesia in Infants and Children. Paediatr Anaesth. Published 3 March 2025. doi:10.
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