Comparison of effects of remimazolam and propofol on mask ventilation during general anaesthesia induction: A randomised controlled trial
Authors' conclusion
Compared to propofol, remimazolam induction was associated with easier mask ventilation and more stable blood pressure after LOC, despite a longer time to achieve LOC.
Study context
- Population
- Adults scheduled for elective surgery under GA
- Participants
- 76 adults
- Comparison
- Remimazolam vs propofol for GA induction
- Primary endpoint
- Mask ventilation difficulty (Warters scale)
Primary result
As reported in the abstract
Warters score
Remimazolam
0.0
interval 0.0–0.8
Propofol
1.0
interval 0.0–3.0
P = 0.002
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Mask ventilation difficulty requiring >1 airway device · during induction | 0.23 (0.08–0.68) | P = 0.006 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| Mean BP immediately after LOCHigher in remimazolam | P = 0.037 |
| Time to LOCLonger in remimazolam | P < 0.001 |
Safety
Hypotension after induction
- Incidence comparable between groups
Original publication
Comparison of effects of remimazolam and propofol on mask ventilation during general anaesthesia induction: A randomised controlled trial. Anaesth Crit Care Pain Med. Published 20 November 2025. doi:10.
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