Relationship between effect site concentration of remimazolam at loss of consciousness and time to extubation: a prospective, single-centre, observational study
Authors' conclusion
The effect site concentration of remimazolam at LOC could be useful for determining arousal time.
Study context
- Population
- Patients undergoing laparoscopic surgery under remimazolam GA
- Participants
- 107 patients
- Outcome
- Relationship between the time for remimazolam effect site concentration to return to its level at loss of consciousness (LOC) and recovery of consciousness (ROC)
Methodological detailssingle-centre, Remimazolam dose adjusted to SEF < 16 on SedLine®; BIS, SedLine®, non-invasive CO and effect site concentration monitored simultaneously
- Single-centre
- Remimazolam dose adjusted to SEF < 16 on SedLine®; BIS, SedLine®, non-invasive CO and effect site concentration monitored simultaneously
Main finding
As reported in the abstract
Time from recovery of remimazolam effect site concentration to LOC level until ROC
Median time from recovery of effect site concentration to loss of consciousness (LOC) level until ROC
4.0 min
Observational data: associations, not effects.
Original publication
Relationship between effect site concentration of remimazolam at loss of consciousness and time to extubation: a prospective, single-centre, observational study. J Clin Monit Comput. Published 25 August 2025. doi:10.
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