Pediatric anesthesia & critical care
Comparison of effects of volatile and intravenous anesthetics on pupillary function during general anesthesia in children: A prospective observational study
Main finding · Neurological Pupil indexResult — go to the resultMedian difference 0.30 95% CI 0.00–0.70Authors' conclusion
The Neurological Pupil index value in pediatric patients under general anesthesia is affected by the anesthetic agent used
Study context
- Population
- Children aged 3–12 years scheduled for elective surgery under GA
- Participants
- 20 children
- Exposure
- Sevoflurane vs propofol
- Outcome
- Neurological Pupil index
- Follow-up
- T4, 1 h after skin incision
Methodological detailsrandomly allocated
- Randomly allocated
Main finding
As reported in the abstract
T4
Median difference
0.30
95% CI 0.00–0.70
P = 0.036
Sevoflurane vs Propofol
median difference 0.30 (95% CI 0.00–0.70); P = 0.036
Observational data: associations, not effects.
Secondary outcomes
Neurological Pupil index, all time points
- Lower in the sevoflurane group at all time points
Constriction and dilation velocity (time-and-group interaction)
- Constriction velocity interaction
- F(1, 4) = 16.68, p = .002
- Dilation velocity interaction
- F(1, 4) = 14.78, p = .008
Neurological Pupil index, pupil diameter, % change in pupil diameter (time-and-group interaction)
- No significant interaction effect
Remifentanil flow rate and total infused remifentanil
- No intergroup differences
Original publication
Comparison of effects of volatile and intravenous anesthetics on pupillary function during general anesthesia in children: A prospective observational study. Paediatr Anaesth. Published 16 April 2023. doi:10.
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