Pediatric anesthesia & critical care
Sevoflurane preconditioning in living liver donation is associated with better initial graft function after pediatric transplantation: a retrospective study
Authors' conclusion
Significantly fewer children who received a graft from a donor in whom only sevoflurane was used to maintain anesthesia developed IPGF.
Study context
- Population
- Children who received a living donor liver transplant (LDLT) and their living donors, 2010–2019
- Participants
- 183 donor-recipient pairs
- Exposure
- Propofol vs Sevoflurane vs Propofol with sevoflurane
- Propofoln = 85
- Sevofluranen = 69
- Propofol with sevofluranen = 29
- Outcome
- Initial poor graft function (IPGF) after pediatric transplantation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
IPGF
- Children who developed initial poor graft function (IPGF) (all groups)
- 42 (23%)
- Anesthesia maintenance agent in donor independently associated with IPGF (multivariate logistic regression)
- p = 0.004
Observational data: associations, not effects.
Further findings
Other factors associated with IPGF (multivariate logistic regression)
- Donor age
- P = 0.03
- Duration of transplant surgery
- P = 0.009
- Preoperative recipient neutrophil to lymphocyte ratio
- P = 0.02
- Albumin
- P = 0.05
Original publication
Sevoflurane preconditioning in living liver donation is associated with better initial graft function after pediatric transplantation: a retrospective study. Perioper Med (Lond). Published 28 February 2024. doi:10.
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