Respiratory failure & ventilation
Comparison of prolonged exhalation end-tidal CO₂ and transcutaneous CO₂ monitoring in chronic obstructive pulmonary disease (COPD) patients
Authors' conclusion
PetCO2-PA demonstrated a small bias but a relatively wide LOA with PaCO2, non-inferior to PtcCO2, in patients with COPD.
Study context
- Population
- Patients with COPD (stable phase or acute exacerbation)48 stable, 35 exacerbation
- Participants
- 83 patients
- Comparison
- PetCO2-PA vs PtcCO2, each against PaCO2
- Outcome
- Agreement with PaCO2 (Bland-Altman bias and limits of agreement)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Agreement with PaCO2 (Bland-Altman)
PetCO2-PA
- 2.4
bias · limits of agreement (LOA) - 9.9 to 5.1 · mmHg
PtcCO2
- 1.7
bias · LOA - 8.6 to 5.1 · mmHg
Further findings
Greater than
| Outcome | PetCO2-PA | PtcCO2 |
|---|---|---|
| Diagnostic accuracy for hypercapnia (PaCO2 ≥ 45 or 50 mmHg) | ||
| AUC | 0.94 | 0.94 |
Diagnostic accuracy for hypercapnia (PaCO2 ≥ 45 or 50 mmHg)
- No statistically significant inter-method differences
Measurements exceeding clinical acceptability thresholds (± 4 mmHg and ± 7 mmHg)
- Proportions did not differ significantly between techniques
Original publication
Comparison of prolonged exhalation end-tidal CO₂ and transcutaneous CO₂ monitoring in COPD patients. Crit Care. Published 20 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →