Respiratory failure & ventilation
Prehospital Use of Non‐Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial
- terminated early
- Terminated early due to low recruitment; 111 screened
Authors' conclusion
The clinical effect of prehospital non-invasive ventilation could not be determined due to early termination.
Study context
- Population
- Prehospital patients with suspected acute respiratory failure due to acute exacerbation of COPD with respiratory acidosis (pH < 7.30 and PaCO2 > 6.0 kPa), attended by physician-manned emergency care units14 analysed
- Participants
- 16 patients
- Comparison
- NIV + standard medical treatment vs Standard medical treatment alone
- Primary endpoint
- Change in arterial pH from enrolment to hospital arrival
- Follow-up
- Hospital arrival
Methodological detailsinvestigator-initiated, multicentre, Missing data limited assessment of in-hospital outcomes, Recruitment limited by strict inclusion criteria, procedural complexity and implementation of prehospital arterial blood gas analysis
- Investigator-initiated
- Multicentre
- Missing data limited assessment of in-hospital outcomes
- Recruitment limited by strict inclusion criteria, procedural complexity and implementation of prehospital arterial blood gas analysis
Primary result
As reported in the abstract
Prehospital pH change
NIV + standard medical treatment
0.09
median · IQR 0.02–0.12
Standard medical treatment alone
0.02
median · IQR 0.01–0.03
Further findings
On-scene time
Original publication
Prehospital Use of Non‐Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial. Acta Anaesthesiol Scand. Published 31 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →