Respiratory failure & ventilation
Extracorporeal CO2 elimination for acute exacerbation of severe COPD requiring invasive mechanical ventilation: a randomized controlled trial (the X-COPD trial)
Primary resultResult — go to the resultRisk difference −33% 95% CI −65% to 6%- terminated early
- Terminated early (planned enrollment 192)
Authors' conclusion
In this prematurely terminated trial, ECCO₂R-facilitated early extubation using a device with a capacity to eliminate more than 50% of the average CO2 production, was associated with a shorter duration of invasive mechanical ventilation.
Study context
- Population
- Adults with acute hypercapnic respiratory failure due to acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) requiring invasive mechanical ventilation (IMV) who failed or were ineligible for extubation within 24 h of intubationplanned enrollment 192
- Participants
- 18 adults
- Comparison
- ECCO2R-facilitated early extubation vs standard IMV
- Primary endpoint
- Composite of:
- Death
- Severe disability
- Follow-up
- Day 60
Primary result
As reported in the abstract
Risk difference
−33%
95% CI −65% to 6%
P = 0.21
Events by treatment group
ECCO2R
0
events
IMV
33%
3 events
Secondary outcomes
IMV duration
mean difference −17.2 · P = 0.043
Median ECCO2R 7.0 · IMV 16.0
Device-support-free days · day 29 · post hoc exploratory analysis
P = 0.011
Sedation
- Sedation discontinued earlier in the ECCO2R group
Safety
- VAP occurred in 0 versus 3 patients (37.5%), respectively (ECCO2R vs IMV)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →