Respiratory failure & ventilation
Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial – A Randomized Clinical Trial
- stopped early for slow enrollment
Authors' conclusion
In subjects with exacerbation of COPD, the use of ECCO2R compared with standard care did not improve VFD-5.
Study context
- Population
- Adults with chronic obstructive pulmonary disease (COPD) exacerbation failing noninvasive ventilation (NIV) or failing to wean from invasive mechanical ventilation (IMV), 41 US institutions, 2018–2022of planned 180
- Participants
- 113 adults
- Comparison
- Standard care with venovenous extracorporeal CO2 removal (ECCO2R) vs standard care alone
Methodological detailsmulticentre, stratified (NIV and IMV strata), Group n by stratum: ECCO2R NIV 26, IMV 32; Standard care NIV 22, IMV 33
- Multicentre
- Stratified (NIV and IMV strata)
- Group n by stratum: ECCO2R NIV 26, IMV 32; Standard care NIV 22, IMV 33
Primary result
As reported in the abstract
VFD-5
- ECCO2R vs Standard care: P = 0.36
- Trial stopped early because of slow enrollment
Further findings
VFD-5, NIV stratum (subgroup)
median shift 0.0 (0.0–0.0)
VFD-5, IMV stratum (subgroup)
median shift 0.00 (0.00–1.25)
All-cause in-hospital mortality, IMV stratum · no difference
P = 0.73
All-cause in-hospital mortality, NIV stratum · significantly higher with ECCO2R
P = 0.02
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial – A Randomized Clinical Trial. Am J Respir Crit Care Med. Published 1 March 2024. doi:10.
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