Respiratory failure & ventilation
Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the ICU: An Observational Study From the OUTCOMEREA Database, 1997–2018
Authors' conclusion
The length of stay and mortality of patients with AECOPD admitted to ICUs has decreased over the last 20 years, with a wider use of NIV and a reduction in antibiotic and corticosteroid prescriptions.
Study context
- Population
- Patients admitted to ICUs at 32 French sites for acute exacerbation of COPD, OutcomeRea database, 1997–2018
- Participants
- 1,816 patients
- Exposure
- Trends over time, 1997–2002 vs 2013–2018
- Outcome
- Management and outcomes over time
Methodological detailsmulticentre database, time-series analysis
- Multicentre database
- Time-series analysis
Main finding
As reported in the abstract
- Reduction over time in prescription of corticosteroids and antibiotics; not linked with ICU mortality in time-series analysis
- Proportion treated with invasive mechanical ventilation declined from 51% (1997–2002) to 35% (2013–2018); decrease associated with reduction in ICU mortality in time-series analysis
- Noninvasive ventilation (NIV) failure rates decreased, with increased NIV use to support weaning from invasive mechanical ventilation
- Hospital mortality decreased from 24% (1997–2002) to 15% (2013–2018)
- ICU mortality decreased from 14% (1997–2002) to 10% (2013–2018)
- 90-day mortality decreased from 41% (1997–2002) to 22% (2013–2018)
Observational data: associations, not effects.
Further findings
ICU LOS
Total duration of hospitalisation
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the ICU: An Observational Study From the OUTCOMEREA Database, 1997–2018. Crit Care Med. Published 15 February 2023. doi:10.
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