Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP) in patients with acute exacerbation of COPD: From the French OUTCOMEREA cohort
An erratum to this article was published (Crit Care, 9 Apr 2024 ↗)
Authors' conclusion
We found that NV-ICU-AP incidence reached 10.8/1000 patient-days and was associated with increased risks of intubation, 28-day mortality, and longer stay for patients admitted with AECOPD.
Study context
- Population
- ICU patients with severe acute exacerbation of COPD managed without immediate invasive mechanical ventilation, French OutcomeRea database
- Participants
- 844 COPD exacerbations
- Exposure
- NV-ICU-AP vs no NV-ICU-AP
- NV-ICU-APn = 42
- Outcome
- Factors associated with NV-ICU-AP occurrence; association of NV-ICU-AP with outcomes
Methodological detailsmulticentre database, competing risk survival analysis
- Multicentre database
- Competing risk survival analysis
Main finding
As reported in the abstract
NV-ICU-AP occurrence
NV-ICU-AP occurred
42 patients
5%
Incidence density per 1,000 patient-days
10.8
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| 28-day mortality · adjusted for confounders | HR 3.03 (CI 1.36–6.73) | P < 0.01 | |
| IntubationAdjusted for confounders | csHR 5.00 (CI 2.54–9.85) | P < 0.01 | |
| 0.10.31310Ratio (log scale) |
| Outcome | Increase (days) | P value |
|---|---|---|
| ICU LOSAdjusted for confounders | 10 | P < 0.01 |
Original publication
Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP) in patients with acute exacerbation of COPD: From the French OUTCOMEREA cohort. Crit Care. Published 19 September 2023. doi:10.
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