Comparison of the efficacy and safety of ciprofol and propofol for endoscopic retrograde cholangiopancreatography (ERCP) anesthesia in older patients: A single-center randomized controlled clinical study
Authors' conclusion
Compared with propofol, ciprofol exhibited a comparable level of sedation in older patients undergoing ERCP, and recovery was safe and rapid with less injection pain.
Study context
- Population
- Older patients scheduled for ERCP
- Participants
- 284 patients
- Comparison
- Ciprofol vs propofol for ERCP anesthesia
- Ciprofoln = 142
- Propofoln = 142reference
- Primary endpoint
- Sedation success rate (proportion with successful anesthesia induction)
Methodological detailssingle-centre, parallel, non-inferiority, General Hospital of Northern Theater Command; November 2021 to June 2022
- Single-centre
- Parallel
- Non-inferiority
- General Hospital of Northern Theater Command; November 2021 to June 2022
Primary result
As reported in the abstract
Sedation success rate
95 % CI - 2.63 %, 2.63 %
Secondary outcomes
Time of successful sedation induction · longer with ciprofol
P < 0.05
Time of complete recovery · shorter with ciprofol
P < 0.05
Time of leaving the room · shorter with ciprofol
P < 0.05
Safety
Injection pain · lower with ciprofol
P < 0.05
Other outcomes (hypoxemia, hypotension)
- Other outcomes didn't show statistical differences
Original publication
Comparison of the efficacy and safety of ciprofol and propofol for ERCP anesthesia in older patients: A single-center randomized controlled clinical study. J Clin Anesth. Published 16 September 2024. doi:10.
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