Efficacy and safety of Ciprofol for procedural sedation and anesthesia in non-operating room settings
Authors' conclusion
Ciprofol induced a level of sedation or anesthesia equivalent to that induced by propofol in non-operating room settings except for a prolonged induction time in patients undergoing FB. Ciprofol had a safety profile similar to that of propofol. No pain on injection was reported by ciprofol.
Study context
- Population
- Patients scheduled for an endoscopic procedure (endoscopic submucosal dissection, ERCP, flexible bronchoscopy) in non-operating room settings, university-affiliated teaching hospital
- Participants
- 207 patients
- Comparison
- Ciprofol 6 or 8 mg/kg/h vs propofol 40 mg/kg/h (induction dose) for sedation or anaesthesia
- Ciprofol 6 mg/kg/hn = 69
- Ciprofol 8 mg/kg/hn = 69
- Propofoln = 69reference
- Primary endpoint
- Success rate of sedation or anesthesia for the procedures
Methodological detailsprospective, double-blind, parallel-group, single-centre
- Prospective
- Double-blind
- Parallel-group
- Single-centre
Primary result
As reported in the abstract
Procedure success rate
Secondary outcomes
Induction time, flexible bronchoscopy (subgroup) — Ciprofol 6 mg/kg/h and Ciprofol 8 mg/kg/h vs Propofol · longer with ciprofol only in FB
P = 0.004
| Outcome | P value |
|---|---|
| Time to full alertness and PACU dischargeCiprofol 6 mg/kg/h, Ciprofol 8 mg/kg/h vs Propofol | P > 0.05 |
Time to full alertness and PACU discharge
- Comparable across the three groups
Neurological outcomes and inflammatory responses
- Comparable among the three groups
Safety
Drug-related AEs
Pain on injection
- No pain on injection reported in ciprofol groups
Original publication
Efficacy and safety of Ciprofol for procedural sedation and anesthesia in non-operating room settings. J Clin Anesth. Published 2 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →