Respiratory failure & ventilation
High-flow nasal cannula improves pulmonary gas exchange during endoscopic retrograde cholangiopancreatography: A single-center randomized controlled trial
Authors' conclusion
HFNC did not reduce the incidence of hypoxemic events. However, it resulted in a reduction of hypercapnic events.
Study context
- Population
- Adults undergoing endoscopic retrograde cholangiopancreatography procedures (ERCP) under deep sedation38% with obstructive sleep apnea (OSA)
- Participants
- 191 adults
- Comparison
- High flow nasal cannula (HFNC) vs standard low-flow nasal cannula (NC)
- HFNCn = 92
- NCn = 99reference
- Primary endpoint
- Incidence of hypoxemic events (SpO2 < 90% lasting ≥15 s)
Methodological detailssingle-centre, 1:1 randomisation stratified by OSA
- Single-centre
- 1:1 randomisation stratified by OSA
Primary result
As reported in the abstract
Hypoxemic events
HFNC
3
events
NC
13
events
P = 0.05
Secondary outcomes
PtCO2
P < 0.005
AUC for SpO2 < 90% (post-hoc) · post-hoc analysis
P < 0.001
Airway rescue maneuvers (all patients)
- Needed airway rescue maneuvers, overall
- 64 (33%)
- Exploratory outcome
Original publication
High-flow nasal cannula improves pulmonary gas exchange during endoscopic retrograde cholangiopancreatography: A single-center randomized controlled trial. J Clin Anesth. Published 27 March 2026. doi:10.
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