Respiratory failure & ventilation
Weaning Strategies for High-Flow Nasal Cannula in Critically Ill Adults: A Randomized Clinical Trial
Authors' conclusion
In this randomized trial, no statistically significant differences were observed among the three HFNC weaning strategies in terms of weaning success or duration.
Study context
- Population
- Adults (≥ 18 yr old) in the ICU who met the weaning criteria after receiving high-flow nasal cannula (HFNC), from three tertiary care hospitalscompleted the trial, 102 patients screened, 15 excluded · flow reduction (FR) 31 · OR 26 · simultaneous reduction (SR) 30
- Participants
- 87 adults
- Comparison
- Three HFNC weaning strategies: flow reduction first, Fio2 reduction first, or simultaneous reduction
- FRn = 31
- ORn = 26
- SRn = 30
- Primary endpoint
- HFNC weaning success rate (successful transition to conventional oxygen therapy without the need for HFNC reapplication, noninvasive ventilation, or endotracheal intubation within 24 hours)
- Follow-up
- 24 hours
Primary result
As reported in the abstract
P = 0.15
Further findings
Weaning duration
P = 0.87
Sex (male) by group · baseline characteristic
- Weaning duration: among the three groups; no statistically significant difference
Original publication
Weaning Strategies for High-Flow Nasal Cannula in Critically Ill Adults: A Randomized Clinical Trial. Crit Care Med. Published 15 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →