Respiratory failure & ventilation
High-Frequency Chest Wall Oscillation in Acute Respiratory Failure With Bronchial Hypersecretion: A Randomized Controlled Trial
Primary result · Therapeutic bronchoscopyResult — go to the resultAdjusted odds ratio 0.336 95% CI 0.111–1.021Authors' conclusion
In this exploratory trial, HFCWO did not significantly reduce the need for therapeutic bronchoscopy after adjustment. Associated reductions in LOS and HFNC duration are hypothesis-generating and require confirmation in adequately powered multicenter trials.
Study context
- Population
- Patients in a RICU with acute respiratory failure (ARF) requiring noninvasive respiratory support (NIRS) (high-flow nasal cannula (HFNC) and/or noninvasive ventilation (NIV)), bronchial hypersecretion, and ineffective cough (peak cough expiratory flow <270 L/min)patients enrolled
- Participants
- Eighty-eight patients
- Comparison
- High-frequency chest wall oscillation (HFCWO) plus standard care or standard care alone
- HFCWOn = 44
- Controln = 44
- Primary endpoint
- Therapeutic bronchoscopy
Primary result
As reported in the abstract
Adjusted odds ratio
0.336
95% CI 0.111–1.021
P = 0.055
Events by treatment group
HFCWO vs control
adjusted OR 0.336 (95% CI 0.111–1.021); P = 0.055
Secondary outcomes
Hospital stay · shorter with HFCWO
adjusted reduction 4.5
RICU stay · shorter with HFCWO · exploratory
adjusted reduction 3.6
HFNC duration · exploratory
| Outcome | P value |
|---|---|
| NIV durationDid not remain significant after adjustment · exploratory | adjusted p=0.166 |
- Hospital stay: exploratory; analyzed without correction for multiple testing
HFNC duration
- Shorter and remained significant after adjustment
Endotracheal intubation and mortality
- No patient required intubation
- Mortality did not differ
- Exploratory
Original publication
High-Frequency Chest Wall Oscillation in Acute Respiratory Failure With Bronchial Hypersecretion: A Randomized Controlled Trial. Chest. Published 14 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →