Respiratory failure & ventilation
Humidified Noninvasive Ventilation versus High-Flow Therapy to Prevent Reintubation in Patients with Obesity: A Randomized Clinical Trial
Authors' conclusion
Among adult critically ill patients with obesity at intermediate risk for extubation failure, the rate of reintubation was not significantly lower with NIV than with HFNC.
Study context
- Population
- Patients with obesity (BMI >30) ready for planned extubation with three or fewer risk factors for reintubation, without hypercapnia at end of SBT; two ICUs in Spain, June 2020-June 2021
- Participants
- 144 patients
- Comparison
- Noninvasive ventilation (NIV) with active humidification vs high-flow nasal cannula (HFNC) for 48 hours after extubation
- NIVn = 72
- HFNCn = 72reference
- Primary endpoint
- Reintubation rate
- Follow-up
- Within 7 days after extubation
Methodological detailstwo-centre, post hoc Bayesian analysis
- Two-centre
- Post hoc Bayesian analysis
Primary result
Reintubation
Difference between groups
9.7
95% CI −4.9 to 24.4
Events by treatment group
NIV vs HFNC
difference between groups 9.7 (95% CI −4.9 to 24.4)
As reported in the abstract
Further findings
Secondary analyses
- All secondary analyses showed nonsignificant differences
Probability of reduction in reintubation with NIV (exploratory Bayesian analysis)
- Data-driven prior
- 99%
- Minimally informative prior
- 90%
- Skeptical prior
- 89%
- Post hoc
Original publication
Humidified Noninvasive Ventilation versus High-Flow Therapy to Prevent Reintubation in Patients with Obesity: A Randomized Clinical Trial. Am J Respir Crit Care Med. Published 1 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →