Perioperative medicine & outcomes
Comparison of the passive mast cell activation test with the basophil activation test for diagnosis of perioperative rocuronium hypersensitivity
Authors' conclusion
We show that the pMAT, in many cases, can substitute for BAT in the diagnosis of rocuronium hypersensitivity and advance diagnosis in difficult cases with uncertain ST or sIgE results when BAT is not locally available.
Study context
- Population
- Patients with suspected perioperative hypersensitivity reaction potentially related to rocuronium, with complete diagnostic investigation (skin tests, sIgE to morphine and rocuronium, basophil activation test (BAT))sera
- Participants
- 90 patients
- Comparison
- pMAT vs BAT
- Outcome
- Agreement of pMAT with BAT
Performance
As reported in the abstract
| Test or model | Positive pMAT among 38 BAT+ | Negative pMAT among 44 BAT- |
|---|---|---|
| pMAT | 25 (66%) | 43 (98%) |
pMAT
Positive pMAT among 38 BAT+25 (66%)
Negative pMAT among 44 BAT-43 (98%)
Further findings
Sera by skin test and sIgE result
- ST+sIgE+
- 41
- ST-sIgE-
- 13
- ST+sIgE-
- 20
- ST-sIgE+
- 16
Non-sensitised mast cells (control)
- Mast cells not passively sensitised did not respond to rocuronium
Original publication
Comparison of the passive mast cell activation test with the basophil activation test for diagnosis of perioperative rocuronium hypersensitivity. Br J Anaesth. Published 6 April 2023. doi:10.
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