Perioperative medicine & outcomes
Diagnostic certainty after investigation of perioperative hypersensitivity: a retrospective cohort analysis
Authors' conclusion
Limitations in the investigative pathway of suspected perioperative hypersensitivity result in diagnostic uncertainty for a substantial proportion of patients.
Study context
- Population
- Adults referred to the Yorkshire Perioperative Hypersensitivity Reactions clinic, UK, for suspected perioperative hypersensitivity, January 2012–March 2025
- Participants
- 565 adults
- Outcome
- Diagnostic certainty (5-point score: >2 clinical features of hypersensitivity, drug given within 15 min of reaction, mast cell tryptase rise, positive skin test, other causal drugs excluded)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Diagnostic certainty
Confirmed hypersensitivity reaction to a culprit drug
407
72%
Highest diagnostic certainty score (5/5), among confirmed
116
29%
Less certain diagnosis, among confirmed
291
71%
Observational data: associations, not effects.
Original publication
Diagnostic certainty after investigation of perioperative hypersensitivity: a retrospective cohort analysis. Br J Anaesth. Published 11 February 2026. doi:10.
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