Comparison of the recovery profiles of propofol, dexmedetomidine, and remimazolam for intraoperative sedation in patients undergoing upper limb surgery under brachial plexus blockade: a randomized controlled trial
Primary result · Recovery timeResult — go to the resultMean difference 5 min 95% CI 3–8Authors' conclusion
Patients in the propofol group exhibited the most rapid recovery time from intraoperative sedation under regional anesthesia, followed by those in the remimazolam and dexmedetomidine groups.
Study context
- Population
- Patients scheduled for upper limb surgery under brachial plexus blockade
- Participants
- 119 patients
- Comparison
- Intraoperative sedation with propofol vs dexmedetomidine vs remimazolam
- Primary endpoint
- Recovery time (from completion of infusion to Modified Observer's Assessment of Alertness and Sedation score of 5)
Primary result
Recovery time
Mean difference
5 min
95% CI 3–8
P < 0.001
By group
Remimazolam vs Propofol
mean difference 5 min (95% CI 3–8); P < 0.001
As reported in the abstract
Secondary outcomes
Recovery-related secondary outcomes (LOS, quality of recovery, Aldrete score)
- No significant differences among the three groups (all P > 0.05)
Original publication
Comparison of the recovery profiles of propofol, dexmedetomidine, and remimazolam for intraoperative sedation in patients undergoing upper limb surgery under brachial plexus blockade: a randomized controlled trial. Can J Anaesth. Published 13 June 2025. doi:10.
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